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Proteomic investigation of thyroid aging and pathogenesis reveals health and disease in thyroid cancers.

ABSTRACT: Understanding thyroid aging is essential for deciphering its physiological and pathological alterations, yet the causal relationship between aging and thyroid disease remains poorly characterized. We conducted a comprehensive proteomic analysis of 6109 thyroid tissues across ages 8-87 from 22 clinical centers (retrospective and prospective cohorts). Using a machine learning-based biological aging clock, we quantified accelerated aging phenotypes in pathological tissues, including benign and malignant nodules. We identified linear and non-linear age-associated proteins and pathways related to metabolism, immune response, and extracellular matrix organization remodeling, with critical transitions observed during the third, sixth, and eighth decades. Cross-species analysis of mouse and monkey tissues uncovered conserved aging markers. Intervention studies suggested that low-protein diets delay thyroid aging in mice, and therapeutic drug screening identified potential anti-tumor candidates. This study establishes the first organ-specific thyroid aging clock, linking tumorigenesis to accelerated aging, and proposing dietary interventions for thyroid longevity.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Thyroid Gland

SUBMITTER: Tiannan Guo

LAB HEAD: Tiannan Guo

PROVIDER: PXD061183 | Pride | 2025-11-04

REPOSITORIES: Pride

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			Action	DRS
	A20221017sunyt_TPD_SHSY_45minDIA_b1_1.raw	Raw
	A20221017sunyt_TPD_SHSY_45minDIA_b1_10.raw	Raw
	A20221017sunyt_TPD_SHSY_45minDIA_b1_11.raw	Raw
	A20221017sunyt_TPD_SHSY_45minDIA_b1_12.raw	Raw
	A20221017sunyt_TPD_SHSY_45minDIA_b1_13.raw	Raw

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