Dataset Information

Parenchymal and Dyshorric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2

ABSTRACT: Whole brain tissue proteomics from rat models of cerebral small vessel disease and Alzheimer's disease, including the rTg-DI model of Cerebral Amyloid Angiopathy (CAA) Type-1, the rTg-D model of CAA Type-2 with both hemizygous and homozygous animals, and the TgSD-AD model of Alzheimer's Disease.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Dennis Province

LAB HEAD: William E. Van Nostrand

PROVIDER: PXD061304 | Pride | 2025-11-17

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	2023_01_UniProt_Rattus_norvegicus.fasta	Fasta
	AD_vs_WT.sne	Other
	AD_vs_WT.tsv	Tabular
	SchraderJ_031623_01_S1-A1_1_2193.mzML	Mzml
	SchraderJ_031623_02_S1-A2_1_2194.mzML	Mzml

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Publications

Parenchymal and Dyshoric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2.

Schrader Joseph M JM Xu Feng F Zhu Xiaoyue X Majchrzak Mark M Davis Judianne J Van Nostrand William E WE

The American journal of pathology 20250717

Cerebral amyloid angiopathy (CAA) is a common age-related disorder, a prominent comorbidity of Alzheimer disease (AD), and causes vascular cognitive impairment and dementia. A previously developed novel transgenic rat model (rTg-D) expresses the human familial CAA Dutch E22Q mutant amyloid β-protein in brain with hemizygous (HEM) animals developing arteriolar CAA type-2 pathology. In this study, homozygous (HOM) rTg-D rats developed more extensive CAA type-2, characterized by abundant fibrillar ...[more]

PMID: 40683561

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