Tandem mass tag (TMT) proteomics sequencing analysis on the lung tissues from 12-week-old wild-type Lmna+/+ and LmnaG609G/G609G mice
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ABSTRACT: Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal condition characterized by premature aging with an average age of death of 14.5 years. Patients with HGPS age at a rate 5 to 10 times faster than normal individuals and are thought to undergo an accelerated version of normal aging.To investigate the mechanisms of HGPS aging, we performed tandem mass tag (TMT) proteomics sequencing analysis on lung tissues from 12-week-old wild-type Lmna+/+ mice and LmnaG609G/G609G mice.Of the upregulated proteins, the Ca2+-binding protein S100A6 was found to be significantly upregulated in the lung tissue of LmnaG609G/G609G mice.
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Lung
SUBMITTER:
weifang Xiang
LAB HEAD: Yu Zhang
PROVIDER: PXD061485 | Pride | 2026-05-16
REPOSITORIES: Pride
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