Proteomics

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Tandem mass tag (TMT) proteomics sequencing analysis on the lung tissues from 12-week-old wild-type Lmna+/+ and LmnaG609G/G609G mice


ABSTRACT: Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal condition characterized by premature aging with an average age of death of 14.5 years. Patients with HGPS age at a rate 5 to 10 times faster than normal individuals and are thought to undergo an accelerated version of normal aging.To investigate the mechanisms of HGPS aging, we performed tandem mass tag (TMT) proteomics sequencing analysis on lung tissues from 12-week-old wild-type Lmna+/+ mice and LmnaG609G/G609G mice.Of the upregulated proteins, the Ca2+-binding protein S100A6 was found to be significantly upregulated in the lung tissue of LmnaG609G/G609G mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

SUBMITTER: weifang Xiang  

LAB HEAD: Yu Zhang

PROVIDER: PXD061485 | Pride | 2026-05-16

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
P20221107119_F.msf Msf
P20221107119_F0.raw Raw
P20221107119_F1.raw Raw
P20221107119_F10.raw Raw
P20221107119_F2.raw Raw
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