Proteomics

Dataset Information

0

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ABSTRACT: This study examines how aging influences the proteomic landscape of human spermatozoa. Proteomic analysis was done on sperm samples from three groups of normal, fertile men: young adults (21–30 years), late adults (31–40 years), and advanced age (41–51 years). The analysis revealed dynamic age-related alterations in human sperm proteins potentially impacting key sperm physiological functions such as motility, metabolism, and fertilization.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Testis, Sperm

DISEASE(S): Infertility

SUBMITTER: Ayodele Alaiya  

LAB HEAD: Dr. Ayodele Alaiya

PROVIDER: PXD062650 | Pride | 2025-07-21

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
ALL-QUANT-IDs-467-ALL-GRPS.csv Csv
EXPORT-PEPTIDE-3D-SPECTRAL-TO-MGF.mgf Mgf
EXPORT_SPECTRAL_LIBRARIES.msp Other
P1-21-30--S-NS-28062022-01.raw.rar Raw
P1-21-30--S-NS-28062022-02.raw.zip Raw
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Publications

Advancing age in men significantly contributes to declining sperm fertility. Information on age-related proteomic changes in spermatozoa is limited. This study involved normal fertile Arab men in three age groups: young adult (21-30 years; <i>n</i> = 6), late adult (31-40 years; <i>n</i> = 7), and advanced age (40-51 years; <i>n</i> = 5). Gradient-purified spermatozoa were analyzed using LC-MS/MS and proteomic data were processed using Progenesis QI (QIfp) v3.0 and UniProt/SwissProt. Significant  ...[more]

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