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Proteomic Changes in Cancer Cell Lines as a Result of Bacterial Infection

ABSTRACT: This study investigates proteomic changes in two human cancer cell lines—A375 (melanoma) and OVCAR3 (ovarian cancer)—after infection with either Staphylococcus aureus (USA300 wildtype or ΔfnbAB mutant) or Salmonella enterica (SL1344). Using label-free quantitative proteomics, we observed that bacterial infections induced widespread remodeling of the host proteome, with mitochondrial and stress-related proteins generally upregulated, and proteins involved in DNA repair, cytoskeletal structure, and vesicle trafficking downregulated. The study highlights how bacterial invasion influences cancer cell responses.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Staphylococcus Aureus (strain Usa300) Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Sl1344

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Melanoma,Malignant Neoplasm Of Ovary

SUBMITTER: Bo Ren

LAB HEAD: David Goodlett

PROVIDER: PXD062673 | Pride | 2025-10-21

REPOSITORIES: Pride

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			Action	DRS
	A375_1.raw	Raw
	A375_2.raw	Raw
	A375_3.raw	Raw
	OVCAR3_1.raw	Raw
	OVCAR3_2.raw	Raw

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