Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture
SUBMITTER: Xin Yan
LAB HEAD: Xin Yan
PROVIDER: PXD024658 | Pride | 2021-07-05
REPOSITORIES: Pride
Yan Xin X Hu Sen S Yang Yan Y Xu Da D Liu Wenxing W Li Ganwu G Cai Wentong W Bu Zhigao Z
Frontiers in cellular and infection microbiology 20210614
<i>Brucella</i>, a notorious intracellular pathogen, causes chronic infections in many mammals, including humans. The twin-arginine translocation (Tat) pathway transports folded proteins across the cytoplasmic membrane; protein substrates translocated by <i>Brucella</i> include ABC transporters, oxidoreductases, and cell envelope biosynthesis proteins. Previously, we showed that a Tat mutant of <i>Brucella melitensis</i> M28 exhibits reduced survival within murine macrophages. In this study, we ...[more]