Dataset Information
FXYD2 interactome in human beta cell line
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Type B Pancreatic Cell, Cell Culture
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: 
Eiji Yoshihara
LAB HEAD: Eiji Yoshihara
PROVIDER: PXD063048 | Pride | 2026-02-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 2023--02-26-Yoshi-PEY3.raw | Raw | |||
| 2023--02-26-Yoshi-PEY4.raw | Raw | |||
| 2023--02-26-Yoshi-PEY5.raw | Raw | |||
| 2023--02-26-Yoshi-PEY6.raw | Raw | |||
| 2023--02-26-Yoshi-PEY7.raw | Raw |
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Publications
FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction.
Nature communications 20250604 1
Human pancreatic islets regulate organ development and metabolic homeostasis, with dysfunction leading to diabetes. Human pluripotent stem cells (hPSCs) provide a potential alternative source to cadaveric human pancreatic islets for replacement therapy in diabetes. However, human islet-like organoids (HILOs) generated from hPSCs in vitro often exhibit heterogeneous immature phenotypes such as aberrant gene expression and inadequate insulin secretion in response to glucose. Here we show that FXYD ...[more]
