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Global profiling of lysine lactylation in prostate cancer cells

ABSTRACT: Lysine lactylation (Kla) is a recently identified post-translational modification derived from lactate that regulates diverse biological processes. Although Kla has been studied in several cancers, its role in prostate cancer (PC) remains unclear. We identified 681 Kla sites across 379 proteins, with modifications predominantly located in nuclear and cytoplasmic proteins. Enrichment analysis indicatedrevealed Kla involvement in mRNA splicing, chromatin organization, and glycolysis/gluconeogenesis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Jaeyong Kim

LAB HEAD: Sangkyu Lee

PROVIDER: PXD063266 | Pride | 2025-11-10

REPOSITORIES: Pride

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			Action	DRS
	LactylSites.xlsx	Xlsx
	PC-3M_Klac_1.raw	Raw
	PC-3M_Klac_2.raw	Raw
	PC-3M_Klac_3.raw	Raw
	checksum.txt	Txt

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Publications

Global Profiling of Lysine Lactylation in Prostate Cancer Cells.

Kim Jae Yong JY Sim Hyunchae H Na Ann-Yae AY Choi So Young SY Lee Sangkyu S

Cancer genomics & proteomics 20251101 6

<h4>Background/aim</h4>Lysine lactylation (Kla) is a recently identified post-translational modification derived from lactate that regulates diverse biological processes. Although Kla has been studied in several cancers, its role in prostate cancer (PC) remains unclear. The objective of this study is to profile Kla in PC in order to explore the mechanisms involved in PC progression.<h4>Materials and methods</h4>We performed global Kla profiling in PC-3M prostate cancer cells using affinity enric ...[more]

PMID: 41151862

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