Proteomics

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Unraveling the Regulatory Impact of Hnf1aos1 on Hepatic Homeostasis

ABSTRACT: Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression, playing significant roles in tissue development and disease progression. The antisense lncRNA Hnf1aos1 represents a particularly intriguing regulatory molecule in liver biology, functioning as a negative regulator of HNF1α and involved in cytochrome P450 enzyme regulation and epigenetic mechanisms. Despite the growing recognition of lncRNAs in liver diseases, the comprehensive role of Hnf1aos1 in liver function remains poorly understood. This study aims to investigate the effects of Hnf1aos1 knockdown on liver function, gene expression, and cellular processes using a mouse model to uncover potential therapeutic targets for liver disorders.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Jen Liddle  

LAB HEAD: Dr. Jeremy Balsbaugh

PROVIDER: PXD063297 | Pride | 2025-08-04

REPOSITORIES: Pride

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Unraveling the Regulatory Impact of LncRNA Hnf1aos1 on Hepatic Homeostasis in Mice.

Armanios Beshoy B   Jin Jing J   Kolmel Holly H   Laddha Ankit P AP   Mishra Neha N   Manautou Jose E JE   Zhong Xiao-Bo XB  

Non-coding RNA 20250704 4

<b>Background/Objectives:</b> Long non-coding RNAs (lncRNAs) play significant roles in tissue development and disease progression and have emerged as crucial regulators of gene expression. The hepatocyte nuclear factor alpha antisense RNA 1 (HNF1A-AS1) lncRNA is a particularly intriguing regulatory molecule in liver biology that is involved in the regulation of cytochrome P450 enzymes via epigenetic mechanisms. Despite the growing recognition of lncRNAs in liver disease, the comprehensive role o  ...[more]

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