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Tear Proteome Analysis Using LC-MS/MS in Patients with Primary Nasolacrimal Duct Obstruction

ABSTRACT: The pathogenesis of primary acquired nasolacrimal duct obstruction (PANDO) remains unclear, with several factors implicated, including anatomical structures, hormones, and tear components. This study explores tear proteins to better understand PANDO etiology by comparing protein expression in tears from PANDO patients and healthy controls.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Tear

DISEASE(S): Excessive Tearing

SUBMITTER: Won Seok Bang

LAB HEAD: Jong-Moon Park

PROVIDER: PXD063414 | Pride | 2025-07-21

REPOSITORIES: Pride

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			Action	DRS
	1A16.mzML	Mzml
	1A18.mzML	Mzml
	1A20.mzML	Mzml
	1A21.mzML	Mzml
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Tear Proteome Analysis with Patients with Primary Nasolacrimal Duct Obstruction.

Bang Wonseok W You Heejeong H Park Jong-Moon JM Park Junyoung J Kang Byeongsoo B Ju Minjung M Park Yelin Y Lee Hookeun H Back Seunghoon S Lew Helen H

International journal of molecular sciences 20250704 13

The pathogenesis of primary acquired nasolacrimal duct obstruction (PANDO) remains unclear, with several factors implicated, including anatomical structures, hormones, and tear components. This study explored tear proteins to better understand PANDO etiology by comparing protein expression in tears from patients with PANDO and healthy controls. Tear samples were collected from 22 patients with PANDO (mucous and membranous types) and 8 controls using Weck-Cel sponges. Protein analysis was conduct ...[more]

PMID: 40650225

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