Proteomics

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NSD2 is upregulated by high-risk HPV E6/E7 and modulates epithelial differentiation in HPV-associated Head and Neck Cancer

ABSTRACT: Epigenetic alterations are a key hallmark of cancer and are increasingly recognized as promising clinical biomarkers and therapeutic targets. Head and Neck Squamous Cell Carcinomas (HNSCC) are classified into two subtypes: HPV-positive (HPV+), driven by human papillomavirus (HPV) infections, and the HPV-negative (HPV-), associated with environmental risk factors. Although exhibiting distinct molecular and clinicopathological features, both subtypes lack effective, tailored therapies. Profiling their epigenetic landscape could thus have important clinical implications. In this study, we employed a quantitative mass spectrometry approach to profile histone post-translational modification (hPTMs) in HPV+ and HPV- HNSCC.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Head And Neck Cancer Cell

SUBMITTER: Roberta Noberini  

LAB HEAD: Tiziana Bonaldi

PROVIDER: PXD064152 | Pride | 2026-02-20

REPOSITORIES: Pride

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Cells1907.zip Other
FFPE2208.zip Other
FFPE2308.zip Other
HF190703_RN_HN_104.raw Raw
HF190703_RN_HN_10A.raw Raw
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NSD2 upregulation is driven by high-risk HPV E6/E7 and disrupts epithelial differentiation in HPV-associated head and neck cancer.

Ghiani Lavinia L   Citro Simona S   Medda Alessandro A   Doni Mirko M   Ghoryani Farkhondeh F   Noberini Roberta R   Croci Ottavio O   Maffini Fausto F   Miccolo Claudia C   Monteleone Laura L   Tagliabue Marta M   De Berardinis Rita R   Campaner Stefano S   Bonaldi Tiziana T   Ansarin Mohssen M   Chiocca Susanna S  

Journal of experimental & clinical cancer research : CR 20260108 1

BACKGROUND: Head and Neck Squamous Cell Carcinoma (HNSCC) are classified in two main subtypes: HPV-positive (HPV+), driven by human papillomavirus (HPV) infections, and HPV-negative (HPV-), associated with environmental risk factors. Despite molecular and clinicopathological differences, neither subtype has effective tailored therapies. Since high-risk HPV oncoproteins E6/E7 affect several epigenetic regulators, characterizing the epigenetic landscape of HPV+ and HPV- HNSCC may uncover novel sub  ...[more]

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