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NSD2 is upregulated by high-risk HPV E6/E7 and modulates epithelial differentiation in HPV-associated Head and Neck Cancer

ABSTRACT: Epigenetic alterations are a key hallmark of cancer and are increasingly recognized as promising clinical biomarkers and therapeutic targets. Head and Neck Squamous Cell Carcinomas (HNSCC) are classified into two subtypes: HPV-positive (HPV+), driven by human papillomavirus (HPV) infections, and the HPV-negative (HPV-), associated with environmental risk factors. Although exhibiting distinct molecular and clinicopathological features, both subtypes lack effective, tailored therapies. Profiling their epigenetic landscape could thus have important clinical implications. In this study, we employed a quantitative mass spectrometry approach to profile histone post-translational modification (hPTMs) in HPV+ and HPV- HNSCC.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Head And Neck Cancer Cell

SUBMITTER: Roberta Noberini

LAB HEAD: Tiziana Bonaldi

PROVIDER: PXD064152 | Pride | 2026-02-20

REPOSITORIES: Pride

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			Action	DRS
	Cells1907.zip	Other
	FFPE2208.zip	Other
	FFPE2308.zip	Other
	HF190703_RN_HN_104.raw	Raw
	HF190703_RN_HN_10A.raw	Raw

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Publications

NSD2 upregulation is driven by high-risk HPV E6/E7 and disrupts epithelial differentiation in HPV-associated head and neck cancer.

Ghiani Lavinia L Citro Simona S Medda Alessandro A Doni Mirko M Ghoryani Farkhondeh F Noberini Roberta R Croci Ottavio O Maffini Fausto F Miccolo Claudia C Monteleone Laura L Tagliabue Marta M De Berardinis Rita R Campaner Stefano S Bonaldi Tiziana T Ansarin Mohssen M Chiocca Susanna S

Journal of experimental & clinical cancer research : CR 20260108 1

PMID: 41507992

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