Dataset Information
Hippocampal proteome in human model of Temporal Lobe Epilepsy
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Temporal Lobe Epilepsy
SUBMITTER: 
Marc-Michel Wilson
LAB HEAD: Gary, P, Brennan
PROVIDER: PXD064519 | Pride | 2025-07-28
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 2022_02_03_GaryBrennan_C01.raw | Raw | |||
| 2022_02_03_GaryBrennan_C02.raw | Raw | |||
| 2022_02_03_GaryBrennan_C03.raw | Raw | |||
| 2022_02_03_GaryBrennan_C04.raw | Raw | |||
| 2022_02_03_GaryBrennan_C05.raw | Raw |
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Publications
N6-methyladenosine (m6A) dysregulation contributes to network excitability in temporal lobe epilepsy.
JCI insight 20250722 14
Analogous to DNA methylation and protein phosphorylation, it is now well understood that RNA is also subject to extensive processing and modification. N6-methyladenosine (m6A) is the most abundant internal RNA modification and regulates RNA fate in several ways, including stability and translational efficiency. The role of m6A in both experimental and human epilepsy remains unknown. Here, we used transcriptome-wide m6A arrays to obtain a detailed analysis of the hippocampal m6A-ome from both mou ...[more]
