Dataset Information
Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Blood Plasma
DISEASE(S): Plasmodium Falciparum Malaria
SUBMITTER: 
Teresa Nunez
LAB HEAD: Thierry Le Bihan
PROVIDER: PXD064525 | Pride | 2026-02-23
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 110-so0410-Asn-Ev-V1.raw | Raw | |||
| 110-so0410-Chy-Ev-V1.raw | Raw | |||
| 110-so0410-Lyc-Ev-V1.raw | Raw | |||
| 110-so0410-Pep-Ev-V1.raw | Raw | |||
| 110-so0410-Try-Ev-V1.raw | Raw |
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Publications
Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child.
Proceedings of the National Academy of Sciences of the United States of America 20250820 34
<i>Plasmodium falciparum</i> pathology is driven by the accumulation of parasite-infected erythrocytes in blood capillaries. This sequestration process is mediated by the parasite's <i>P. falciparum</i> erythrocyte membrane protein 1 (PfEMP1) adhesins, which bind select endothelial cell receptors. A subset of PfEMP1 binding human endothelial protein C receptor (EPCR) through their cysteine-rich interdomain region alpha 1 (CIDRα1) domains drives the pathogenesis to severe malaria. Despite high se ...[more]
