Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child

ABSTRACT: Plasmodium falciparum pathology is driven by the accumulation of parasite-infected erythrocytes in blood capillaries. We demonstrate a novel approach to identify pathogen-specific human monoclonal antibodies directly from plasma, combining mass-spectrometry analysis of antigen-purified polyclonal plasma IgG with Ig transcript sequencing.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Blood Plasma

DISEASE(S): Plasmodium Falciparum Malaria

SUBMITTER: Teresa Nunez  

LAB HEAD: Thierry Le Bihan

PROVIDER: PXD064525 | Pride | 2026-02-23

REPOSITORIES: Pride