Dataset Information

The Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons-APEX2 proteome analysis

ABSTRACT: We and others previously reported that knock-in mice expressing the pathogenic hyperactive Lrrk2G2019S mutation, exhibit deficits in dopamine release within the striatum. To investigate the underlying molecular mechanisms, we conducted axonal proteome analysis of a subcluster within vulnerable Aldh1a1+ dopamine axons, defined by Annexin 1 (Anxa1+), confirmed subtle proteomic changes across comparisons

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Chuyu Chen

LAB HEAD: Loukia Parisiadou

PROVIDER: PXD065003 | Pride | 2026-05-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	2024-09-06_Northwestern_Biognosys_Results_unfiltered.xlsx	Xlsx
	Q_D240216_MDIA_P4388_SExp01-BID001_R01.raw	Raw
	Q_D240216_MDIA_P4388_SExp01-BID002_R01.raw	Raw
	Q_D240216_MDIA_P4388_SExp01-BID005_R01.raw	Raw
	Q_D240216_MDIA_P4388_SExp01-BID006_R01.raw	Raw

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Publications

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons.

Chen Chuyu C He Qianzi Q Tombesi Giulia G Napier Eve E Jaconelli Matthew M Moreno-Ramos Oscar Andrés OA Serio Hannah H Naaldijk Yahaira Y Promes Vanessa V Schneeweis Amanda A Quinn Kaitlyn K Nasios Christopher C Greggio Elisa E Kozorovitskiy Yevgenia Y Arango Daniel D Khan Amir R AR Alessi Dario R DR Dombeck Daniel A DA Hilfiker Sabine S Awatramani Rajeshwar R Parisiadou Loukia L

bioRxiv : the preprint server for biology 20250903

The end-stage pathology of Parkinson's disease (PD) involves the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). However, synaptic deregulation of these neurons begins much earlier. Understanding the mechanisms behind synaptic deficits is crucial for early therapeutic intervention, yet these remain largely unknown. In the SNc, different dopamine neuron subtypes show varying susceptibility patterns to PD, complicating our understanding. This study uses intersection ...[more]

PMID: 40909700

Dataset Information

The Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons-APEX2 proteome analysis

Dataset's files

Publications

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons.

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