Proteomics

Dataset Information

Shiga toxin-positive extracellular vesicles induce higher mortality and more kidney injury than free toxin

ABSTRACT: Escherichia coli O157:H7 is a non-invasive Shiga toxin (Stx)-producing pathogen that causes gastroenteritis and hemolytic uremic syndrome characterized by acute kidney injury. Stx binding to cells induces release of extracellular vesicles (EVs) containing the toxin. This study aimed to demonstrate the lethal effects of toxin-positive vesicles compared to free toxin, and the importance of the Stx receptor, globotriaosylceramide (Gb3), for these effects.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Markus Wendler  

LAB HEAD: Diana Karpman

PROVIDER: PXD065687 | Pride | 2026-06-23

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20250527_091632_240828_LB_H2505_9170_Karpman_EVs_Report.log.txt Txt
20250527_091632_240828_LB_H2505_9170_Karpman_EVs_Report.params Other
20250527_091632_240828_LB_H2505_9170_Karpman_EVs_Report.setup.txt Txt
20250527_091632_240828_LB_H2505_9170_Karpman_EVs_Report.tsv Tabular
20250527_091632_240828_LB_H2505_9170_Karpman_EVs_paired.sne Other
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