Dataset Information

Serum Proteomic Profiling Reveals Immune and Inflammatory Mechanisms Driving Susceptibility to Buffalo Fly-Induced Skin Lesions in Cattle

ABSTRACT: Buffalo fly (Haematobia irritans exigua) infestation in cattle poses a significant challenge to animal health and welfare, causing blood loss and often painful skin lesions. These lesions can reduce the value of cattle in saleyards, make cattle unacceptable for certain markets, and provide a focus for secondary infections; yet, the underlying mechanisms of susceptibility remain poorly understood. This study employed SWATH-MS-based quantitative proteomics to investigate systemic proteomic profiles in lesion-susceptible (HL) and lesion-resistant (NL) cattle across multiple time points, aiming to identify key proteins and pathways associated with lesion development and resilience.

INSTRUMENT(S):

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Blood Serum

SUBMITTER: Ali Raza

LAB HEAD: Ali Raza

PROVIDER: PXD066231 | Pride | 2026-01-12

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20230221_BFL_Ali_Lib.tsv	Tabular
	20230221_Nanxi_L0-1.wiff	Wiff
	20230221_Nanxi_L0-1.wiff.scan	Wiff
	20230221_Nanxi_L0-2.wiff	Wiff
	20230221_Nanxi_L0-2.wiff.scan	Wiff

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Publications

Serum proteomic profiling reveals immune and inflammatory mechanisms driving susceptibility to buffalo fly-induced skin lesions in cattle.

Raza Ali A Naseem Muhammad Noman MN Kamran Muhammad M Nouwens Amanda A Juli Mst Sogra Banu MSB Constantinoiu Constantin C Tabor Ala A Schulz Benjamin B James Peter P

Scientific reports 20251203 1

Buffalo fly (Haematobia irritans exigua) infestation in cattle poses a significant challenge to animal health and welfare, causing blood loss and often painful skin lesions. These lesions can reduce the value of cattle in saleyards, make cattle unacceptable for certain markets, and provide a focus for secondary infections; yet, the underlying mechanisms of susceptibility remain poorly understood. In this study, we performed longitudinal serum proteomic profiling of high-lesion (HL; lesion-suscep ...[more]

PMID: 41339694

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