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Proteomics from Triple-Negative Breast Cancer from the MMTV-R26Met Model

ABSTRACT: We have developed the MMTV-R26Met mouse model, which exclusively generates TNBC and recapitulates key features of the human disease in an immunocompetent setting. In this study, we provide a proteomics characterization of MMTV-R26Met-derived tumors. This integrative approach reveals distinct tumor clusters that reflect patient-like heterogeneity and provides a valuable framework for TNBC stratification and therapeutic development.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

DISEASE(S): Brain Cancer

SUBMITTER: Luc Camoin

LAB HEAD: Luc Camoin

PROVIDER: PXD067482 | Pride | 2026-01-16

REPOSITORIES: Pride

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			Action	DRS
	DIANN.zip	Other
	H10_6micro.raw	Raw
	H10_6micro_20231003112001.raw	Raw
	H11_6micro.raw	Raw
	H11_6micro_20231003160926.raw	Raw

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Publications

Multi-omics profiling uncovers immune-molecular clusters with distinct chemo-immunotherapeutic vulnerabilities in a mouse model of triple-negative breast cancer.

Castellanet Olivier O Monatte Jean J Corvaisier Nathan N Kaoutari Abdessamad El AE Kaya Muge M Ferreira Lorène L Audebert Stephane S Camoin Luc L de Nonneville Alexandre A Gonçalves Anthony A Borg Jean-Paul JP Michea Paula P Maina Flavio F Lamballe Fabienne F

Molecular cancer 20260110

<h4>Background</h4>Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous breast cancer subtype with limited treatment options. Predicting patient response to chemo-immunotherapy remains challenging, highlighting the need for robust stratification strategies.<h4>Methods</h4>We performed a multi-parametric analysis combining histological, genomic, transcriptomic, proteomic, and immune profiling in the immunocompetent MMTV-R26<sup>Met</sup> TNBC mouse model and compared outc ...[more]

PMID: 41520125

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