Title Heme acts as a molecular degrader linking CRL2-FEM1B to substrate proteolysis and ferroptosis regulation in lung cancer

ABSTRACT: In this project, we attempted to explore the differential proteins profile of lung cancer cells in which the BACH1-CRL2 pathway was manipulated. To this end, we performed DIA-based quantitative proteomics in mouse lung adenocarcinoma KP cells. Control cells and BACH1 null cells were used. Additionally, the expression of CRL2 was silenced using siRNA. A cell line transfected with an siCTRL was used as negative control. 3 biological replicates were used for each sample group.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Malignant Cell

DISEASE(S): Lung Adenocarcinoma

SUBMITTER: AUDEBERT Stephane  

LAB HEAD: Dr Luca Lignitto

PROVIDER: PXD062953 | Pride | 2026-06-11

REPOSITORIES: Pride