Targeting SKAP2-modulated cytoskeleton remodeling restores sperm motility

ABSTRACT: Our work recognized heterogeneous nuclear ribonucleoprotein R (hnRNPR) is a master regulator of m6A-dependent pre-mRNA splicing. Genetic mutation in HNRNPR leads to asthenoteratozoospermia in both humans and mice, culminating in complete sterility. Mechanistically, genetic ablation of Hnrnpr manifests widespread transcriptomic, proteomics, and m6A-modified splicing dysregulation, disrupting these genes essential for acrosome formation and flagellum development.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Sperm

SUBMITTER: Jiaming Zhou  

LAB HEAD: Shiming Gan

PROVIDER: PXD067981 | Pride | 2025-09-13

REPOSITORIES: Pride