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Unveiling the venom proteome of Red-tailed bamboo Pit Viper (Trimeresurus erythrurus)

ABSTRACT: Trimeresurus erythrurus, more popularly known as Red-tailed bamboo Pit Viper, is among the venomous Indian snakes that do not belong to the "Big Four" snake species. The project aims to unveil the venom proteome of Red-tailed bamboo Pit Viper (Trimeresurus erythrurus) from northeastern India.

INSTRUMENT(S):

ORGANISM(S): Trimeresurus Erythrurus

TISSUE(S): Epithelial Cell, Saliva

SUBMITTER: Rahul Kumar

LAB HEAD: Microbial biotechnology and protein research loaboratory

PROVIDER: PXD068023 | Pride | 2026-06-17

REPOSITORIES: Pride

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	IASST_B10_VK_170225_1.raw	Raw
	IASST_B10_VK_170225_1.xlsx	Xlsx
	IASST_B11_VK_170225_1.raw	Raw
	IASST_B11_VK_170225_1.xlsx	Xlsx
	IASST_B1_DVN_170225_1.raw	Raw

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Publications

Quantitative proteomic analysis to comprehend the Trimeresurus erythrurus (Red-Tailed Bamboo Pit Viper) venom proteins (toxins) and their correlation with lethality, preclinical toxicity, and clinical manifestations in envenomed patients.

Kumar Rahul R Mahato Rosy R Baruah Sunyana S Lalremsanga Hmar Tlawmte HT Kalita Bhargab B Mukherjee Ashis K AK

International journal of biological macromolecules 20251103 Pt 1

Snakebite remains a significant health burden in tropical and subtropical regions, including India, which is home to several venomous snake species. The red-tailed bamboo pit viper (Trimeresurus erythrurus), which is distributed in northeast India, is a medically important yet poorly studied species. This study presents the first comprehensive proteomic and functional characterization of T. erythrurus venom (TEV). Label-free quantitative proteomics identified 159 proteins spanning 14 venom prote ...[more]

PMID: 41192703

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Unveiling the venom proteome of Pope's Pit Viper (Trimeresusrus popeiorum)

Project description:Trimeresurus popeiorum, more popularly known as Pope's Pit Viper, is among the venomous Indian snakes that do not belong to the "Big Four" snake species. The project aims to unveil the venom proteome of Pope's Pit Viper (Trimeresusrus popeiorum) from northeastern India.

2025-03-19 | PXD057471 | Pride

Fangs in the ghats: preclinical insights into the medical importance of endemic pit vipers from the Western Ghats

Project description:The socioeconomic burden of snakebite in India is largely attributed to the ‘big four’ snakes, completely neglecting the considerable impact of envenoming by many other snake species. Bites from the so-called ‘neglected many’ are often treated with a polyvalent antivenom that is manufactured against the ‘big four’ snakes - a strategy that has been widely documented to fail. Yet, specific antivenoms are not commercially manufactured against these snakes. While the medical importance of various species of cobras, saw-scaled vipers, and kraits is very well-known, the clinical impact of pit vipers from the rainforests of the Western Ghats, northeastern India, and Andaman and Nicobar islands has remained elusive. Amongst the 90+ species of snakes found in the Western Ghats, the hump-nosed (Hypnale hypnale), Malabar (Craspedocephalus malabaricus) and bamboo (Craspedocephalus gramineus) pit vipers can potentially inflict clinically severe envenoming in humans. To evaluate the severity of toxicity inflicted by these snakes, we characterised their venom composition, biochemical and pharmacological activities, and toxicity- and morbidity-inducing potentials. Our findings highlight the therapeutic inadequacies of the generic Indian and Hypnale-specific Sri Lankan polyvalent antivenoms in neutralising morbidity and mortality resulting from pit viper envenomings and underscore the need for a regional antivenom therapy in India.

2023-07-20 | PXD039139 | Pride

Proteomics of Hypnale hypnale (Hump-nosed pit viper) venom from the Western Ghats of India

Project description:Hypnale hypnale (hump-nosed pit viper) is considered to be one among the medically important venomous snake species of India and Sri Lanka. In the present study, venom proteome profiling of a single Hypnale hypnale from Western Ghats of India was achieved using SDS-PAGE based protein separation followed by LC-MS/MS analysis

2020-03-19 | PXD017592 | Pride

Venomics of the Okinawa Habu pit viper Protobothrops flavoviridis

Project description:Comprehensive snake venomics of the Okinawa Habu pit viper, Protobothrops flavoviridis, by complementary mass spectrometry-guided approaches

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Proteomics of venom from Trimeresurus malabaricus

Project description:This project mainly aims to characterize the complex toxic components present in the venom of Trimeresurus malabaricus (Malabar pit viper). Since Trimeresurus malabaricus (Malabar pit viper) species are mainly inhabited to plantation crop areas, its envenomation is a serious threat to the human population thriving in these zones, especially to the plantation workers. Therefore, exploring the venom proteome of Malabar pit viper is decisive to develop and design new antivenom and therapeutics against its envenomation. As described in this study, applying various orthogonal separation strategies helped in dissecting venom constituents of Trimeresurus malabaricus and is the first comprehensive attempt in revealing the complex venom profile of Malabar pit viper through proteomics approaches incorporating multiple database searches. In order to achieve this the crude venom components were resolved on a 12% SDS page. Further each of the bands were subjected to in-gel trypsin digestion. The crude venom was also subjected to ion-exchange chromatography separation. The obtained fractions were subjected to in-solution trypsin digestion. All the digested peptides were then subjected to Q-TOF LC-MS/MS analysis.

2020-01-24 | PXD011673 | Pride

Venomics of the horned desert Viper (Cerastes Cerastes) and the mangrove pit viper (Cryptelytrops purpureomaculatus)

Project description:In this study two Viperidae species, living in two different habitats, the horned desert viper (Cerastes cerastes) native to the deserts in North Africa and in turn the mangrove pit viper (Cryptelytrops purpureomaculatus), which can be found in South/Southeast Asia, were studied in terms of the identification of the venom proteome.

2018-08-07 | MSV000082753 | MassIVE

Project description:Transcriptome of Shedao pit-viper and black eyebrow pit-viper

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Pit-1 overexpression in the human breast adenocarcinoma MCF-7 cell line

Project description:The aim of the study is to evaluate Pit-1-induced genes in the MCF-7 cell line The Pit-1 transcription factor (also known as POU1F1) plays a critical role in cell differentiation during organogenesis of the anterior pituitary in mammals and is a transcriptional activator for pituitary gene transcription. Increased expression of Pit-1 has been reported in human tumorigenic breast cells. Here, we found that Pit-1 overexpression or knockdown in human breast cancer cell lines induced profound phenotypic changes in the expression of proteins involved in cell proliferation, apoptosis, and invasion. In immunodeficient mice, Pit-1 overexpression induced tumoral growth and promoted metastasis in lung. In patients with invasive ductal carcinoma of the breast and node-positive tumors elevated expression of Pit-1 was significantly and independently associated with the occurrence of distant metastasis. These findings suggest that Pit-1 could help to make a more accurate prognosis in patients with node positive breast cancer and may represent a new therapeutic target (Journal of Clinical Investigation 2010, 120:4289-4302)

2014-12-12 | GSE64101 | GEO

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Pit-1 overexpression in the human breast adenocarcinoma MCF-7 cell line

2014-12-12 | E-GEOD-64101 | biostudies-arrayexpress