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Plasma Extracellular Vesicles from PSEN1-E280A and APOE3 Christchurch patients

ABSTRACT: We isolated plasma EVs from MCI PSEN1E280A-APOE3 (n=10, mean age: 46, range 41-54), non-MCI PSEN1E280A-APOE3 (n=10, mean age: 34, range 22-48), and non-MCI PSEN1E280A-APOE3Ch (n=9, mean age: 35, range 16-51) participants, using differential centrifugation. EVs were characterized by nanoparticle tracking analysis, flow cytometry and LC-MS/MS analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Platelet, Blood Cell, Blood Plasma, Astrocyte, Pericyte Cell

DISEASE(S): Alzheimer's Disease

SUBMITTER: Lina Pineda

LAB HEAD: Rafael Posada-Duque

PROVIDER: PXD068363 | Pride | 2026-02-02

REPOSITORIES: Pride

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			Action	DRS
	112365_CNT_10.raw	Raw
	112366_MCI_E280A_9.raw	Raw
	112367_Non_MCI_E280A_Ch_8.raw	Raw
	112368_Ch_10.raw	Raw
	112369_Non_MCI_E280A_Ch-Ch_9.raw	Raw

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Publications

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease.

Pineda-Lopez Lina L Aguillon David D Villar-Vesga Juan J Valderrama-Carmona Pablo P Guerrero Alejandro A Upreti Anil A Arevalo-Alquichire Said S Correa Laura L Mendez-Castellanos Karin K Castaño Diana D Cardona-Gomez Gloria P GP Fernandez Geysson J GJ Kim Leo A LA Arboleda-Velasquez Joseph F JF Posada-Duque Rafael R

Alzheimer's & dementia : the journal of the Alzheimer's Association 20260101 1

<h4>Introduction</h4>The PSEN1<sup>E280A</sup> mutation causes autosomal dominant Alzheimer's disease (ADAD) with predictable onset, enabling presymptomatic studies. Extracellular vesicles (EVs) are emerging biomarkers of cognitive decline, but their role in early ADAD is unclear. The rare apolipoprotein E (APOE3) Christchurch (APOE3<sup>Ch</sup>) variant delays disease onset, yet its effect on EVs is unknown.<h4>Methods</h4>We analyzed plasma EVs from mild cognitive impairment (MCI) and non-MCI ...[more]

PMID: 41566550

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