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Label-free quantitative proteomics of Achilles and tail tendon fascicles from WT and VHL KO mice

ABSTRACT: Tendon integrity depends on controlled extracellular matrix production and adaptation to mechanical load. Dysregulated hypoxia-inducible factor 1α (HIF1α) signaling has been linked to human tendon disease. To investigate the effects of chronic HIF1α activation and to compare responses between load-bearing Achilles tendons and positional tail tendon fascicles, we generated a tendon-specific VHL knockout in SCX-positive cells and performed label-free proteomics to characterize matrix remodeling.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Fibroblast, Tendon

SUBMITTER: Greta Moschini

LAB HEAD: Jess Gerrit Snedeker

PROVIDER: PXD069118 | Pride | 2025-11-24

REPOSITORIES: Pride

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			Action	DRS
	VHL_KO_Achilles65.raw	Raw
	VHL_KO_Achilles66.raw	Raw
	VHL_KO_Achilles79.raw	Raw
	VHL_KO_Achilles80.raw	Raw
	VHL_KO_Achilles90.raw	Raw

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Proteomic profiling of tendon-specific VHL knockout and VHL-dependent double knockout mouse tail tendon fascicles

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