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RHOT proteins link mitochondrial motility to cardiomyocyte sarcomere maturation.

ABSTRACT: Proteome and phosphoproteome analysis of left ventricular tissue obtained from mice with embryonic, cardiomyocyte-selective deletion of Rhot1/2 (cRhot1/2-KO) and controls (cRhot1/2-Con) at 1-day and 4-weeks of age.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Felix Polten

LAB HEAD: Christian Riehle

PROVIDER: PXD069555 | Pride | 2026-04-30

REPOSITORIES: Pride

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			Action	DRS
	LV_Phosphoproteom_TMT_P1_F1.raw	Raw
	LV_Phosphoproteom_TMT_P1_F18.raw	Raw
	LV_Phosphoproteom_TMT_P1_F2.raw	Raw
	LV_Phosphoproteom_TMT_P1_F3.raw	Raw
	LV_Phosphoproteom_TMT_P1_F4.raw	Raw

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RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation.

Froese Natali N Shymotiuk Ivanna I Froese Alexander A Polten Felix F Jablinski Jonas J Scholz Tim T Korf-Klingebiel Mortimer M Werlein Christopher C Galuppo Paolo P Gigina Anna A Wihler Katharina K Schneider Johanna J Erschow Sergej S Heimerl Maren M Szaroszyk Malgorzata M Hegermann Jan J Wrede Christoph C Schweitzer Theresa T Pich Andreas A Geffers Robert R Ricke-Hoch Melanie M Kühnel Mark P MP Jonigk Danny D DD Wende Adam R AR Abel E Dale ED Nikolaev Viacheslav O VO Wollert Kai C KC Bauersachs Johann J Riehle Christian C

Circulation research 20260316 9

<h4>Background</h4>Cardiomyocyte mitochondria align with sarcomeres during heart development. Mitochondrial motility is controlled by RHOT (ras homolog family member T) 1 and RHOT2. RHOT1 and RHOT2 are atypical Rho-like small GTPases that are anchored to the outer mitochondrial membrane and couple mitochondria to kinesin and dynein motors. We hypothesized that RHOT protein expression and mitochondrial motility are required for mitochondrial positioning during cardiomyocyte development.<h4>Method ...[more]

PMID: 41834725

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RHOT proteins link mitochondrial motility to cardiomyocyte sarcomere maturation.

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RHOT proteins link mitochondrial motility to cardiomyocyte sarcomere maturation

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RHOT proteins link mitochondrial motility to cardiomyocyte sarcomere maturation

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Analysis of the transcriptome of adult cardiac myocytes stimulated with CTGF

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