Proteomics

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Plasma Proteomics Analysis of a Transglutaminase 2 inhibitor in Celiac Disease

ABSTRACT: Individuals with celiac disease (CeD) on a long-term gluten-free diet (GFD) underwent a 6-week gluten challenge combined with 100mg per day of the transglutaminase 2 enzyme -inhibitor, ZED1227 (PGCd, n = 28) or placebo (PGCp, n = 19). The samples were collected at baseline (GFD) and post-gluten challenge (PGC). Mass spectrometry-based lipidomic and proteomics profiling, along with genome-wide DNA methylation analysis, were applied to plasma samples obtained from 47 CeD patients. Comparative analyses were performed between the groups, with adjustment for BMI, age, sex, and country of origin.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Celiac Disease

SUBMITTER: Robert Moulder  

LAB HEAD: Professor Riitta Lahesmaa

PROVIDER: PXD069597 | Pride | 2026-06-15

REPOSITORIES: Pride

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Dataset's files

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Action DRS
220118_Evo_HF_DIA33_Serum800ng_Pool2.raw Raw
220118_Evo_HF_DIA33_Serum800ng_TG2_A02.raw Raw
220118_Evo_HF_DIA33_Serum800ng_TG2_A05.raw Raw
220118_Evo_HF_DIA33_Serum800ng_TG2_A09.raw Raw
220118_Evo_HF_DIA33_Serum800ng_TG2_B02.raw Raw
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Publications

BACKGROUND: Celiac disease (CeD) is an autoimmune disease triggered by dietary gluten in genetically predisposed individuals. Deamidation of gluten peptides by the CeD autoantigen and enzyme transglutaminase 2 (TG2) is central to the pathogenesis of CeD. Inhibition of TG2 with the specific inhibitor ZED1227 effectively prevents gluten-induced histological damage in CeD patients. Here we aimed to explore the systemic plasma lipidomic, proteomic and DNA methylomic changes in ZED1227-treated CeD pa  ...[more]

PMID: 42032651

Publication: 1/2

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