Proteomics

Dataset Information

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Proteomic Analysis of Patient-Derived Lung Tumoroids and Matched Organoids Compared to Parental Tumors and Tissues

ABSTRACT: Proteomic characterization of patient-derived lung tumoroids and matched healthy lung organoids compared to their parental tumor and healthy lung tissues from NSCLC patients. The study validates that tumoroids preserve tumor-specific proteomic signatures and identifies proteomic signatures potentially driving resistance and susceptibility to standard of care and CAR T-cell therapy. Comparative analyses assess preservation of tumor proteomic landscapes, differential expression between tumor and healthy samples, and tumor-associated antigen expression profiles.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Epithelial Cell

DISEASE(S): Non-small Cell Lung Carcinoma

SUBMITTER: Lukas Ehlen  

LAB HEAD: Michael Schmueck-Henneresse

PROVIDER: PXD070147 | Pride | 2026-04-27

REPOSITORIES: pride

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Dataset's files

Source:
Action DRS
AG-MSH-10MS-LUCO-4_BD4_1_203.d.quant Other
AG-MSH-10MS-LUCO-4_BD4_1_203.d.zip Other
AG-MSH-11MS-LUCO-8_BD8_1_207.d.quant Other
AG-MSH-11MS-LUCO-8_BD8_1_207.d.zip Other
AG-MSH-12MS-LUCO-12_BE4_1_211.d.quant Other
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Publications

Lung tumouroids as a testing platform for precision CAR T cell therapy.

Ehlen Lukas L   Farrera-Sal Martí M   Szyska Martin M   Arndt Janine J   Schallenberg Simon S   Scholz Cedric C   Yang Mingxing M   Vollbrecht Claudia C   Löwa Anna A   Friedrich Rebecca R   Mai Marco M   Peter Lena L   Picht Samira S   Schulenberg Sarah S   Geray Daniel D   Korus Gabriela G   Sommerfeld Anke A   Treue Denise D   Strauchmann Julia J   Elsner Aron A   Kath Jonas J   Vallone Valeria Fernandez VF   Joosten Maria M   Klatte-Schulz Franka F   Petersen Ansgar A   Stachelscheid Harald H   Wagner Dimitrios L DL   Spies Claudia C   Rückert Jens-Carsten JC   Hocke Andreas C AC   Polansky Julia K JK   Stark Regina R   Klein Oliver O   Schmueck-Henneresse Michael M  

Nature biomedical engineering 20260121 4

Lung cancer, the leading cause of cancer-related mortality, presents major challenges for both standard therapies and chimeric antigen receptor (CAR) T cell therapy due to tumour heterogeneity and resistance. Preclinical models that capture patient-specific factors are essential for personalizing treatment decisions. Here we show that matched lung tumouroids and healthy lung organoids derived from patients provide a robust platform for studying therapy responses. The tumouroids faithfully retain  ...[more]

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