Proteomic Analysis of Patient-Derived Lung Tumoroids and Matched Organoids Compared to Parental Tumors and Tissues

ABSTRACT: Proteomic characterization of patient-derived lung tumoroids and matched healthy lung organoids compared to their parental tumor and healthy lung tissues from NSCLC patients. The study validates that tumoroids preserve tumor-specific proteomic signatures and identifies proteomic signatures potentially driving resistance and susceptibility to standard of care and CAR T-cell therapy. Comparative analyses assess preservation of tumor proteomic landscapes, differential expression between tumor and healthy samples, and tumor-associated antigen expression profiles.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Epithelial Cell

DISEASE(S): Non-small Cell Lung Carcinoma

SUBMITTER: Lukas Ehlen  

LAB HEAD: Michael Schmueck-Henneresse

PROVIDER: PXD070147 | Pride | 2026-04-27

REPOSITORIES: Pride