Proteomics

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Tumour Endothelial Cell Reprogramming Orchestrates Angiocrine Signalling to Drive Chemoresistance in Breast Cancer

ABSTRACT: Phosphoproteomic analysis was performed to decipher changes occurring in tumour cells after treatment with conditioned media from endothelial cells, which may protect them from doxorubicin damage, and promote resistance to the treatment. Briefly, MMTV-PyMT (mouse mammary tumour virus-polyoma middle tumour-antigen) derived tumour cells were pretreated with conditional media from endothelial cells isolated from MMTV tumours treated with doxorubicin for 24 hours, andthen treated afterwards with vehicle (PBS) or doxorubicin in culture for 45 minutes and 2 days.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Breast Epithelial Cell, Epithelial Cell

DISEASE(S): Breast Cancer

SUBMITTER: Vinothini Rajeeve  

LAB HEAD: Maruan Hijazi Vega

PROVIDER: PXD070990 | Pride | 2026-06-29

REPOSITORIES: Pride

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F009473.dat Other
F009474.dat Other
F009475.dat Other
F009476.dat Other
F009477.dat Other
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Publications

Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer.

Gomez-Escudero Jesus J   Maniati Eleni E   Holdsworth Julie J   Beattie Gordon G   Hijazi Maruan M   Guelbert Matt M   Elorbany Samar S   Cutillas Pedro P   Wang Jun J   Hodivala-Dilke Kairbaan K   D'Amico Gabriela G  

Angiogenesis 20260622 3

Despite its established role in breast cancer treatment, Doxorubicin treatment remains subject to adaptive resistance mechanisms that extend beyond cancer cell intrinsic alterations ultimately reducing therapy efficacy. Our study in a MMTV-PyMT-driven mouse breast cancer model reveals that prolonged Doxorubicin (Dox) exposure triggers significant reprogramming of the tumour vasculature, substantially altering the angiocrine landscape and shaping treatment outcomes. Notably, tumours that initiall  ...[more]

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