Proteomics

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Comprehensive proteogenomic analysis identifies immune targets in microsatellite stable and unstable colorectal cancers

ABSTRACT: Immunotherapy in colorectal cancer (CRC) has largely focused on microsatellite instability (MSI) tumors, based on the assumption that high mutational burden drives immunogenicity. However, most CRCs are microsatellite-stable (MSS) and remain unresponsive to checkpoint blockade. Using proteogenomic profiling of 26 primary CRC tumors, we identified 115,292 MHC-I–associated peptides across 61 HLA alleles, yielding 196 tumor-associated antigens (TAAs) and 70 aberrantly expressed tumor-specific antigens (aeTSAs).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

DISEASE(S): Colon Cancer

SUBMITTER: Courcelles Mathieu  

LAB HEAD: Pierre Thibault

PROVIDER: PXD071022 | Pride | 2026-05-26

REPOSITORIES: Pride

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Dataset's files

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Action DRS
1055698F_1_mtechuman_3__PP854__JJ_uploaded_file_id_1811.fasta Fasta
1055698F_CRC_200323_1.mgf Mgf
1055698F_CRC_200323_1.raw Raw
1055698F_CRC_200323_2.mgf Mgf
1055698F_CRC_200323_2.raw Raw
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Publications

Non-canonical transcription and splicing shape the colorectal cancer immunopeptidome in MSI and MSS tumors.

Courcelles Mathieu M   Hardy Marie-Pierre MP   Durette Chantal C   Lanoix Joel J   Minati Robin R   Laverdure Jean-Philippe JP   Vincent Krystel K   Perreault Claude C   Thibault Pierre P  

Molecular & cellular proteomics : MCP 20260507

Treatment with immune checkpoint inhibitors in colorectal cancer (CRC) has largely benefited patients with microsatellite instability-high (MSI-H) and not the larger proportion of patient with microsatellite-stable (MSS) tumors. This clinical dichotomy has fueled the view that high mutational burden is the dominant driver of tumor immunogenicity and that MSS CRC fails to respond because it is "antigen poor". To directly test this premise and define the origins of presented tumor antigens, we int  ...[more]

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