Proteomics of Extracellular Vesicles from hiPSC-Derived Cardiac Organoids

ABSTRACT: Human cardiac organoids were derived from hiPSCs using a regimen of small molecules and morphogens. Extracellular vesicles (cardEVs) were subsequently isolated from the conditioned medium via differential centrifugation. Finally, the proteomic cargo of cardEVs was characterized using LC-MS/MS and bioinformatically compared against EVs derived from the AC10 cardiomyocyte cell line and cadaveric human heart explants (heEVs).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

SUBMITTER: Rune Matthiesen  

LAB HEAD: Rune Matthiesen

PROVIDER: PXD072207 | Pride | 2026-02-02

REPOSITORIES: Pride