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HiPSC-derived Mesendoderm cells LC-MSMS

ABSTRACT: NONO deficiency in hiPSCs results in a distinct defect in early cardiomyocyte differentiation. Mechanistically, NONO interacts with HOXA1 and regulates the dynamic expression of key genes during early cardiomyocyte differentiation. ChIP-seq analysis reveals that NONO loss reduces HOXA1 occupancy at target genes, compromising its transcriptional regulation. Additionally, NONO and HOXA1 cooperatively activate the Wnt signaling.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Zhiyu Feng

LAB HEAD: Guoying Huang

PROVIDER: PXD072401 | Pride | 2025-12-28

REPOSITORIES: Pride

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			Action	DRS
	NONO-KO.raw	Raw
	WT.raw	Raw
	checksum.txt	Txt
	msms.txt	Txt
	peptides.txt	Txt

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