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Proteomic of rabbit fumer defects renconstructed by 4D metamaterials

ABSTRACT: 4D printing, integrating the temporal dimension into 3D printing, offers transformative potential for bone implants. Yet its application to metallic materials is constrained by the scarcity of suitable alloys and the requirement for harsh external stimuli to trigger shape change. Here, we introduce 4D printed metallic metamaterials (4DMM) driven by controlled biodegradation. The 4DMM combine biodegradable constraints (e.g., Mg or Zn) with biometals of higher corrosion potential (e.g., Ti). Upon electrochemical degradation of the constraint, the metamaterials recover their original geometry—via stretching, bending, or expansion—generating programmable recoil forces tuned through structural design parameters. When developed as scaffolds for bone implants, 4DMM exhibit excellent cytocompatibility and, in vivo, promote superior bone regeneration through the synergistic effects of bioactivity and mechanical stimulation. This strategy establishes a new paradigm in 4D metal printing via metamaterial design, enabling bioactive, self-restoring implants with broad applicability across biomedical engineering.

INSTRUMENT(S):

ORGANISM(S): Oryctolagus Cuniculus (rabbit)

TISSUE(S): Bone Matrix

SUBMITTER: Yu Qin

LAB HEAD: Yu Qin

PROVIDER: PXD072881 | Pride | 2026-05-04

REPOSITORIES: Pride

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			Action	DRS
	122901-1_RA1_1_12788.d.rar	Other
	122901-2_RA1_1_12790.d.rar	Other
	122901-3_RA1_1_12792.d.rar	Other
	122901-4_RA1_1_12794.d.rar	Other
	122901-5_RA1_1_12796.d.rar	Other

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4D printing of metallic metamaterials for bone implants via biodegradation

Project description:4D printing, integrating the temporal dimension into 3D printing, offers transformative potential for bone implants. Yet its application to metallic materials is constrained by the scarcity of suitable alloys and the requirement for harsh external stimuli to trigger shape change. Here, we introduce 4D printed metallic metamaterials (4DMM) driven by controlled biodegradation. The 4DMM combine biodegradable constraints (e.g., Mg or Zn) with biometals of higher corrosion potential (e.g., Ti). Upon electrochemical degradation of the constraint, the metamaterials recover their original geometry—via stretching, bending, or expansion—generating programmable recoil forces tuned through structural design parameters. When developed as scaffolds for bone implants, 4DMM exhibit excellent cytocompatibility and, in vivo, promote superior bone regeneration through the synergistic effects of bioactivity and mechanical stimulation. This strategy establishes a new paradigm in 4D metal printing via metamaterial design, enabling bioactive, self-restoring implants with broad applicability across biomedical engineering.

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Gene expression profiling of macrophages: Implications for an immunosuppressive effect of dissolucytotic gold ions

Project description:Gold salts has been used in the treatment of rheumatoid arthritis but has been replaced by biologicals such as TNF-alpha inhibitors. The mechanisms behind the anti-inflammatory effect of metallic gold ions are still unknown, however, recent data showed that charged gold atoms are released from pure metallic gold implants by macrophages via a dissolucytosis membrane, and that gold ions are taken up by local macrophages, mast cells and to some extent fibroblasts. These current findings offer new treatment options for metallic gold and deeper understanding of the effect of metallic gold on key inflammatory cells as macrophages are essential. In the present study the impact of phagocytised gold ions on the global gene expression profile of the human monocytic cell line THP-1 was investigated, using microarray analysis comprising approximately 20,000 genes. The gene expression data was confirmed by measurement of three secreted proteins. A unique gene expression signature of dissolucytotic macrophages that had taken up gold ions was demonstrated. A large number of regulated genes were functionally related to immunomodulation/protection. Gold ion uptake into macrophages induced downregulation of central inflammatory cytokines as TNF-alpha, IL-32 and CD28. The data obtained in this study offer new insights into the mode of action of gold ions and suggest a future role of metallic gold as implants or topical applications in treating inflammation. To determine the effect of gold phagocytosis on global gene expression

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Gene expression profiling of macrophages: Implications for an immunosuppressive effect of dissolucytotic gold ions

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Lower Elastic Modulus of Novel Zr58Cu25Al14Nb3 Dental Implants Improves Stress Distribution and Osteogenesis in Peri-implant Alveolar Bone Under Physiological Loading

Project description:While implant materials with bone-mimetic elastic moduli are theoretically advantageous for reducing the stress shielding effect, the underlying mechanism remains incompletely understood, particularly in alveolar bone applications. In this study, we investigate the mechanism of excellent peri-implant bone quality of a Zr58Cu25Al14Nb3 bulk metallic glass (Nb3) dental implant in terms of its lower elastic modulus than commercial pure titanium (cpTi) and the stress distribution under masticatory mechanical loading. In vitro, Nb3 exhibits enhanced osteogenic potential over cpTi. In vivo, rat maxillary molar implants are subjected to a controllable cyclic loading program (10 N, 3 Hz, 0.12 s duration, 1800 cycles/day). The animal model coupled finite element analysis confirms that the lower elastic modulus of Nb3 implants promotes the more physiological stress distribution, and thus reduces stress concentration while increasing strain energy density in peri-implant bone. Histomorphometry reveals that loaded Nb3 implants significantly accelerate mineral apposition rate, upregulate collagen III, and increase osteoblast density while reducing osteocyte number, demonstrating improved mechano-adaptation. Transcriptomics identify coordinated upregulation of osteogenic, angiogenic, and mechanosensitive markers in Nb3-loaded bone. Immunohistochemistry validates elevated expression of osteopontin and periostin, key mediators of mechanical signaling. These findings establish that Nb3’s optimal elastic modulus enhances peri-implant bone quality through biomechanical optimization of stress transfer that further activates mechanotransductive osteogenesis, providing a material-based solution to stress shielding.

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Project description:Background: Due to their excellent mechanical and biocompatibility properties, titanium-based implants are successfully used as biomedical devices. However, when new bone formation fails for different reasons, impaired fracture healing will become a clinical problem and will affect the patient's quality of life. This study proposes to design a new bioactive surface of titanium implants with a synergetic PEG biopolymer-based composition for gradual delivery of growth factors (FGF2, VEGF, and BMP4) during bone healing. Methods: The optimal architecture of non-cytotoxic polymeric coatings deposited by dip coating under controlled parameters was assessed both in cultured cells and on rat in vivo animal model (100% viability). Results: Notably, the titanium adsorbed polymer matrix induced an improved healing process when compared with the individual action of each biomolecules. High-performance mass spectrometry analysis demonstrated that recovery after a traumatic event is governed by specific differentially regulated proteins, acting in a coordinated response to the external stimulus. Predicted protein interactions shown by STRING analysis were well organized in hub-based networks related with response to chemical, wound healing and response to stress pathways. Conclusions: The described functional polymer coatings of the titanium implants demonstrated the significant improvement of bone healing process after injury.

2021-04-29 | PXD016135 | Pride

A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties (HUVEC)

Project description:Tantalum (Ta) metal is well known for its ideal corrosion resistance and biological effects as endosseous implants. However, the metal has a elastic modulus as high as 186GPa which is not comparable to the natural bone (10-40GPa), and it also has a relative high cost. Here, to fully exploit the advantages of Ta as endosseous implants, a small amount of Ta (as low as 3 at.%) was successfully added into a zirconium-based metallic glass (MG) to generate an advanced functional endosseous implant, Zr58Cu25Al14Ta3 MG, with superior comprehensive properties. Upon carefully dissecting the surface chemistry and atomic structure, the results show that amorphization of Ta enable the uniform distribution in material surface, leading to a significantly improved chemical stability and extensive material-cell contact regulation. Systematical analyses on the immunological, angiogenesis and osteogenesis capability of the material is carried out by utilizing the next-generation sequencing, revealing that Zr58Cu25Al14Ta3 MG can regulate angiogenesis through VEFG signaling pathway and osteogenesis via BMP signaling pathway. Animal experiment further confirms a sound osseointegration of Zr58Cu25Al14Ta3 MG in achieving better bone-implant-contact and inducing faster peri-implant bone formation.

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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties (BMSC)

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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevent properties (xenograft)

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Cancer stem cells from lobular infiltrating breast tumor metastasize to bone and acquire a gene signature associated to bone tropism

Project description:We investigated the role of breast cancer stem-like cells (CSCs-like), isolated from primary tumor, in promoting bone metastases in a human-in-mice model. Luciferase-transduced CD44+CD24- breast CSCs-like were injected through subcutaneous (SC) and intracardiac (IC) route in nonobese/severe combined immunodeficient (NOD/SCID) mice carrying subcutaneous human bone implants. The implanted bone was viable, active and human neo-vascularization was present. By in vivo luciferase imaging, we monitored tumor growth and detected bone-localized breast CSCs-like, both after SC and IC injection. Bone metastatic lesions were histologically evident, and tumor cells expressed epithelial markers and vimentin. Bone metastatic cells isolated from bone implants showed a CD44-CD24+ phenotype and re-created tumors and bone metastases after injection in secondary mice. A “bone tropism” expression signature was found to distinguish bone-colonizing cells from parental CSCs-like and to persist at subsequent passages also in the absence of surrounding bone tissue. The bone tropism signature displayed significant enrichment in genes discriminating bone metastases of breast cancer from metastases at other organs. Our results demonstrate the ability of breast CSCs-like to promote bone metastasis and provide a CSCs-like bone tropism signature, with potential prognostic value. C10 breast cancer stem-like cells (CSCs-like) were derived as mammospheres from a lobular-infiltrating breast carcinoma (ER+, HER2-). Samples are organized in the following groups: (i) Breast CSCs-like (C10, duplicate); (ii) Luciferase-transduced CSCs-like (C10L, simplicate); (iii) Bone-isolated C10L metastatic cells (C10-bone, duplicate) and subsequently (iv) grown in vitro as spheroids (C10-CSC, simplicate) or (v) re-grown in subcutaneous implants (C10-SC, duplicate).

2013-11-30 | E-GEOD-36102 | biostudies-arrayexpress

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