Gene expression profiling of macrophages: Implications for an immunosuppressive effect of dissolucytotic gold ions

ABSTRACT: Gold salts has been used in the treatment of rheumatoid arthritis but has been replaced by biologicals such as TNF-alpha inhibitors. The mechanisms behind the anti-inflammatory effect of metallic gold ions are still unknown, however, recent data showed that charged gold atoms are released from pure metallic gold implants by macrophages via a dissolucytosis membrane, and that gold ions are taken up by local macrophages, mast cells and to some extent fibroblasts. These current findings offer new treatment options for metallic gold and deeper understanding of the effect of metallic gold on key inflammatory cells as macrophages are essential. In the present study the impact of phagocytised gold ions on the global gene expression profile of the human monocytic cell line THP-1 was investigated,

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Geffers 

PROVIDER: E-GEOD-37814 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress