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Multiple self-healing palmoplantar carcinoma (MSPC) proteomics

ABSTRACT: Multiple self-healing palmoplantar carcinoma (MSPC) is one such syndrome, characterized by the appearance of recurrent keratoacanthomas (KAs) on the palms and soles. Here, we compare healthy skin, hyperkeratotic inflammatory lesion (HL), and MSPC-associated KA samples.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Keratinocyte, Skin

SUBMITTER: Roua Popescu

LAB HEAD: George Catalin Marinescu

PROVIDER: PXD073302 | Pride | 2026-06-08

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	HL_run1.wiff	Wiff
	HL_run1.wiff.scan	Wiff
	HL_run2.wiff	Wiff
	HL_run2.wiff.scan	Wiff
	HL_run3.wiff	Wiff

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Publications

Mast Cells Are a Reservoir of NLRP1 in Human Skin.

Dobre Alexandra A Fertig Tudor Emanuel TE Niculae Andrei Marian AM Cohn Adelina Maria AM Curici Antoanela A Andrei Razvan Theodor RT Marta Daciana Silvia DS Peteu Victor Eduard VE Popescu Roua Gabriela RG Marinescu George Catalin GC Turcu Gabriela G Forsea Ana Maria AM Ion Daniela Adriana DA Gherghiceanu Mihaela M Nedelcu Roxana Ioana RI

International journal of molecular sciences 20260423 9

NLRP1 is an inflammasome sensor protein expressed in barrier tissues of humans. Its activation in response to microbes or cellular stress triggers a cascade of molecular events, leading up to IL1β-driven inflammation and pyroptosis. Rare germline mutations of NLRP1 cause its persistent activation, resulting in autoinflammatory syndromes. Multiple self-healing palmoplantar carcinoma (MSPC) is one such syndrome, characterized by the appearance of recurrent keratoacanthomas (KAs) on the palms and s ...[more]

PMID: 42123364

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