Proteomic Profiling of the 5‑HT2B Receptor Agonist BW723C86 on Migration and Signaling in Mouse Bone Marrow‑Derived Macrophages

ABSTRACT: Mouse Bone marrow-derived macrophages (BMDMs) and HT22 neuronal cells (subjected to 2-hour oxygen-glucose deprivation, OGD-2h) were used in this study. To investigate cell migration, a Transwell assay was performed. For pharmacological intervention, cells were treated with either the serotonin receptor 2B (5-HT2B) agonist BW723C86 or dimethyl sulfoxide (DMSO) as a vehicle control. Following treatment, global protein expression profiling was performed using mass spectrometry-based quantitative proteomics.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Bone Marrow

SUBMITTER: yonghui chen  

LAB HEAD: yueman Zhang

PROVIDER: PXD074138 | Pride | 2026-07-04

REPOSITORIES: Pride