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Exploring the molecular mechanism of bone metastasis in prostate cancer

ABSTRACT: This study focuses on bone metastasis of prostate cancer. By analyzing clinical samples and serum samples, it aims to reveal key molecular mechanisms and explore diagnostic and therapeutic targets. The specific goals include: First, identifying molecular markers related to bone metastasis, using high-throughput sequencing and proteomics analysis to screen for differentially expressed genes, proteins or ssDNA sequences; Second, analyzing the functions and mechanisms of key molecules, clarifying their roles in the interaction between tumor cells and the bone microenvironment through cell and animal experiments; Third, evaluating the potential of ssDNA as a new biomarker, studying its binding characteristics and the application value of liquid biopsy.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Aaron Chen

LAB HEAD: Ye Xiao

PROVIDER: PXD074143 | Pride | 2026-06-01

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	ITGA6-IP.zip	Other
	ITGA6-IP_txt.zip	Other
	PULL_DOWNBiotin-EHBP1-ssDNA_PC-3.zip	Other
	checksum.txt	Txt
	pc-3-protein.zip	Other

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Publications

Single-stranded DNA in the bone microenvironment promotes prostate cancer bone metastasis via the ITGA6-FAK pathway.

Chen Xin X Ye Ming-Sheng MS Peng Zhuo-Lin ZL Yan Feng F Xiao Yuan Y Li Yu-Jue YJ Xiao Ye Y

Communications biology 20260331 1

Bone metastases represent a critical phenotype of prostate cancer progression, driven by factors within the bone microenvironment. However, the molecular mechanisms underlying this progression remain poorly understood. In this study, we observed a significant accumulation of single-stranded DNA within the metastatic bone microenvironment of PCa patients. Through cell-SELEX methodology, we identified a PCa target-specific ssDNA, EHBP1. Specifically, EHBP1-ssDNA specifically captures PCa cells by ...[more]

PMID: 41917316

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