DIA-based Proteomic analysis of human islets with treatment of a PERK inhibitor

ABSTRACT: Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucidate the beta-cell enhancing mechanisms of PERK attenuation.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreatic Islet Cell

SUBMITTER: Dohyun Han  

LAB HEAD: Dohyun Han

PROVIDER: PXD074587 | Pride | 2026-06-29

REPOSITORIES: Pride