Glycoproteomics of Human and Mouse Brains in Alzheimer’s Disease

ABSTRACT: This study profiles glycoproteomic changes in human frontal cortex and mouse brain in Alzheimer’s disease models. We compare cognitively normal and AD human brain tissue, and wild-type and 5xFAD mouse brain, to define whether AD-associated hyperglycosylation reflects increased glycosylation of existing proteins. The work is integrated with spatial glycomics and related multiomic analyses to identify disease-associated glycopeptides and glycoproteins linked to neurodegeneration.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: RAMON SUN  

LAB HEAD: Ramon sun

PROVIDER: PXD075438 | Pride | 2026-03-31

REPOSITORIES: Pride