Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8–Aop–Dilp6 axis
Ontology highlight
ABSTRACT: This project examines how adipose tissue regulates systemic metabolism and aging in Drosophila melanogaster through the miRNA-processing enzyme Dicer-1 (Dcr-1). Proteomic profiling of fat bodies from Dcr-1 heterozygous flies was performed to identify molecular changes associated with reduced Dcr-1 activity. The dataset reveals metabolic and stress-response remodeling consistent with reduced insulin/IGF signaling, supporting a model in which decreased Dcr-1 increases Dilp6 expression in the fat body and suppresses Dilp2 secretion from brain insulin-producing cells, promoting longevity.
INSTRUMENT(S):
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Fat Body
SUBMITTER:
Andrés Dekanty
LAB HEAD: Andres Dekanty
PROVIDER: PXD075513 | Pride | 2026-04-13
REPOSITORIES: Pride
ACCESS DATA