Proteomics

Dataset Information

0

Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8–Aop–Dilp6 axis


ABSTRACT: This project examines how adipose tissue regulates systemic metabolism and aging in Drosophila melanogaster through the miRNA-processing enzyme Dicer-1 (Dcr-1). Proteomic profiling of fat bodies from Dcr-1 heterozygous flies was performed to identify molecular changes associated with reduced Dcr-1 activity. The dataset reveals metabolic and stress-response remodeling consistent with reduced insulin/IGF signaling, supporting a model in which decreased Dcr-1 increases Dilp6 expression in the fat body and suppresses Dilp2 secretion from brain insulin-producing cells, promoting longevity.

INSTRUMENT(S):

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Fat Body

SUBMITTER: Andrés Dekanty  

LAB HEAD: Andres Dekanty

PROVIDER: PXD075513 | Pride | 2026-04-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
D1.raw Raw
D2.raw Raw
D3.raw Raw
D4.raw Raw
LFQ_Turno262376.mzTab Mztab
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