Proteomics

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Immune Complex-Induced Migration of Slan+ Non-Classical Monocytes

ABSTRACT: Slan+ Non-Classical Monocytes migrate on immobilized immune complexes. This phenomenon can be blcoked with anti-CD16 blocking antibodies and is therefore thought to be mediated via CD16 (FcyRIII). Nonetheless, other CD16+ cells, such as NK cells or neutrophils, as well as lineage related cells suchs as classical monocytes do not migrate on immobilized immune complexes. We therefore isolated protein content of Slan+ Non-Classical Monocytes after migration immobilized immune complexes to perform phosphoproteomics in order to better understand the underlying signaling pathways inducing the migratory response.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell, Monocyte

SUBMITTER: Frank Stein  

LAB HEAD: Knut Schäkel

PROVIDER: PXD079927 | Pride | 2026-07-09

REPOSITORIES: Pride

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2023-07-10-decoys-contam-UP000005640_HomoSapiens_ID9606_20594entries_26102022_dl11012023.fasta.fas Fasta
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Publications

A gradient of immune complexes induces directional migration and a lupus-associated transcriptional program in Slan<sup>+</sup> non-classical monocytes.

Hertwig Michael M   Oehrl Stephanie S   Döbel Thomas T   Zhang Hao H   Meisel Stefan S   List Amelie A   Schäkel Knut K  

Journal of autoimmunity 20260613

Immune complexes (ICs) play a central role in autoimmune diseases, where they accumulate in tissues, activate Fc gamma receptor-expressing cells, and promote chronic inflammation. However, the role of ICs as directional migratory cues for human leukocytes remains poorly defined. Here, we identify pro-inflammatory Slan + non-classical monocytes (SlanMo), a CD14<sup>dim</sup> CD16<sup>++</sup> monocyte subset, as the only blood leukocyte population that migrates directionally toward ICs. Using in  ...[more]

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