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Mouse gut metagenome

ABSTRACT: The effect of Clostridium butyricum MIYAIRI 588 on the gut microbiome composition of cefoperazone-treated mice

PROVIDER: PRJDB10646 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR250305_1.fastq.gz	Fastqsanger.gz
	DRR250305_2.fastq.gz	Fastqsanger.gz
	DRR250306_1.fastq.gz	Fastqsanger.gz
	DRR250306_2.fastq.gz	Fastqsanger.gz
	DRR250307_1.fastq.gz	Fastqsanger.gz

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mouse gut metagenome

Project description:The effect of Clostridium butyricum MIYAIRI 588 on the gut microbiota and immune response in tumor bearing mice

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Clostridium butyricum MIYAIRI 588-induced protectin D1 has an anti-inflammatory effect on antibiotic-induced intestinal disorder

Project description:Metabolites are thought as the end products in cellular regulatory processes and their levels show the strongest relationships with the phenotype. Previously, we showed that the administration of Clostridium butyricum MIYAIRI 588 (CBM 588) upregulated protectin D1, an anti-inflammatory lipid metabolite, in colon tissue under antibiotic therapy. However, how CBM 588 induces protectin D1 expression and whether the metabolite has anti-inflammatory effects on antibiotic-induced inflammation are unclear. Therefore, here, we evaluated the effect of CBM 588 on lipid metabolism and protectin D1 in gut protection from antibiotic-induced intestinal disorders. In the CBM 588 treatment group, expression levels of genes encoding lipid receptors related to the conversion of DHA to protectin D1, such as polyunsaturated fatty acid (PUFA) receptors, G-protein coupled receptor 120 (GPR120), and 15-lipoxygenase (LOX), were increased in colon tissue. CD4+ cells producing interleukin (IL)-4, the main component of T helper type 2 (Th2) cells that can activate 15-LOX, also increased in CBM 588-treated groups even after clindamycin co-administration. In addition, similar to CBM 588, exogenously administered protectin D1 reduced inflammatory cytokines, while IL-10 and TGF-β1, works as anti-inflammatory cytokines, were increased. Our data revealed that CBM 588 activated 15-LOX to enhance protectin D1 production by increasing IL-4-producing CD4+ cell population in the intestinal tract. Additionally, CBM 588-induced protectin D1 clearly upregulated IL-10-producing CD4+ cells to control antibiotic-induced gut inflammation. We provide new insights into CBM 588-mediated lipid metabolism induction for the treatment of gut inflammatory diseases.

2020-10-14 | MTBLS2087 | MetaboLights

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Project description:Effect of Cordyceps militaris Ethanol Extract on Gut Microbiome Composition of Immunocompromised Mice

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Project description:The effects of Clostridium butyricum against virus infection

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Early Modulation of the Gut Microbiome by Female Sex Hormones Alters Amyloid Pathology and Microglial Function

Project description:It is well-established that women are disproportionately affected by Alzheimer’s disease (AD). The mechanisms underlying this sex-specific disparity are not fully understood, but several factors that are often associated-including interactions of sex hormones, genetic factors, and the gut microbiome-likely contribute to the disease's etiology. Here, we have examined the role of sex hormones and the gut microbiome in mediating A amyloidosis and neuroinflammation in APPPS1-21 mice. We report that postnatal gut microbiome perturbation in female APPPS1-21 mice leads to an elevation in levels of circulating estradiol. Early stage ovariectomy (OVX) leads to a reduction of plasma estradiol that is correlated with a significant alteration of gut microbiome composition and reduction in A pathology. On the other hand, supplementation of OVX-treated animals with estradiol restores A burden and influences gut microbiome composition. The reduction of A pathology with OVX is paralleled by diminished levels of plaque-associated MGnD-type microglia while estradiol supplementation of OVX-treated animals leads to a restoration of activated microglia around plaques. In summary, our investigation elucidates the complex interplay between sex-specific hormonal modulations, gut microbiome dynamics, metabolic perturbations, and microglial functionality in the pathogenesis of Alzheimer's disease.

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Changes of intestinal microbiota in patients with colon cancer before and after chemotherapy and study of probiotic intervention.

Project description:Interventions: Chemotherapy +placebo group:placebo; Chemotherapy + Clostridium butyricum capsules group:Clostridium butyricum capsules Primary outcome(s): Intestinal flora;Nutrition index;Immune index Study Design: Randomized parallel controlled trial

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Project description:The effects of Clostridium butyricum against virus infection 2

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Project description:The effects of Clostridium butyricum against virus infection 3

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Project description:The effects of Clostridium butyricum against virus infection 4

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