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Bacteria

ABSTRACT: Effects of a subchronic and mild social defeat stress on microbiota of murine colon contents

PROVIDER: PRJDB15491 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR459604.fastq.gz	Fastqsanger.gz
	DRR459605.fastq.gz	Fastqsanger.gz
	DRR459606.fastq.gz	Fastqsanger.gz
	DRR459607.fastq.gz	Fastqsanger.gz
	DRR459608.fastq.gz	Fastqsanger.gz

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Expression data from ileum of mice suffered from subchronic and mild social defeat stress

Project description:This study aimed to investigate the effects of depression on transcriptome in ileum using a subchronic and mild social defeat stress (sCSDS) model. In addition to exhibiting social deficit and hyperphagia-like behavior, the sCSDS mice keep much more water in their body than control mice. In order to investigate the effect of social defeat stress on not only central nervous system but also function of gastrointestinal tract, the gene expression in ileum of stressed mice was compared with control mice. We used microarrays to detail the gene expression after 10 days of social defeat stress and identified distinct classes of down-regulated genes during this process.

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Expression data from ileum of mice suffered from subchronic and mild social defeat stress

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RNA sequencing analysis of gene expression in the mPFC of stressed DBA mice given vehicle of KDM5C inhibitor

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Project description:We performed high-throughput profiling of gene expression in aPVT-projectors in the mPFC of DBA2/J mice subjected to subchronic and mild social defeat stress. DBA mice were subjected to 5-day of social defeat stress and then tested their social interaction and anhedonic state. After behavioral tests, mice were divided into five subtypes: SA, social interaction deficit, ANH: anhedonia, SA:ANH, both social dificit and anhedonia, RES, resilience and non-stressed (NS) control. Mice were euthanized for tissue collection. We then conducted the Immunoprecipitation and RNA-seq. Our study provided insights into the understanding of the molecular mechanisms underlying behavioral heterogeneity.

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Project description:Transcription profiling by array of ileum from mouse exposed to subchronic and mild social defeat stress

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BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli

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