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Unidentified

ABSTRACT: NGS-based Biological evaluation of candidate compounds (KAP220162)

PROVIDER: PRJDB19263 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	DRR670463_1.fastq.gz	Fastqsanger.gz
	DRR670463_2.fastq.gz	Fastqsanger.gz
	DRR670464_1.fastq.gz	Fastqsanger.gz
	DRR670464_2.fastq.gz	Fastqsanger.gz
	DRR670465_1.fastq.gz	Fastqsanger.gz

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Project description:We developed a general approach to small molecule library screening called GE-HTS (Gene Expression-Based High Throughput Screening) in which a gene expression signature is used as a surrogate for cellular states and applied it to the identification of compounds inducing the differentiation of acute myeloid leukemia cells. In screening 1,739 compounds, we identified 8 that reliably induced the differentiation signature, and furthermore yielded functional evidence of bona fide differentiation. This SuperSeries is composed of the following subset Series:; GSE976: Gene Expression-Based High Throughput Screening: APL Treatment with Candidate Compounds; GSE982: Gene Expression-Based High Throughput Screening: HL-60 Cell Treatment with Candidate Compounds; GSE983: Gene Expression-Based High Throughput Screening: Primary Patient AML Blasts, Normal Neutrophils, and Normal Monocytes; GSE985: Gene Expression-Based High Throughput Screening: HL-60 Cells Treated with ATRA and PMA Experiment Overall Design: Refer to individual Series

2007-09-20 | E-GEOD-995 | biostudies-arrayexpress

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