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Nematode metagenome

ABSTRACT: Microbial Community and Ovine Host Responses to Early and Late Haemonchus contortus Infection

PROVIDER: PRJDB5400 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR082486_1.fastq.gz	Fastqsanger.gz
	DRR082486_2.fastq.gz	Fastqsanger.gz
	DRR082487_1.fastq.gz	Fastqsanger.gz
	DRR082487_2.fastq.gz	Fastqsanger.gz
	DRR082488_1.fastq.gz	Fastqsanger.gz

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Profiling of differentially expressed genes in sheep T lymphocytes response to Haemonchus contortus infection

Project description:Once Haemonchus contortus infects sheep it receives a series of host attacks, especially those relating to the infected animal’s T lymphocytes immune response. To obtain a systematic genome-wide profiling of the T lymphocyte genes involved, microarrays were used to compare gene expression between 0 days post infection (dpi), 3-5 dpi, 25-30 dpi and 60dpi in infected sheep. In this 853, 242 and 42 differentially expressed genes were acquired in the 3d vs. 0d comparison, the 30d vs. 0d comparison and the 60d vs. 0d comparison, respectively. Gene Ontology and pathway analysis indicated that modulated genes including SUGT1, FCER1G, CD23, IL-13 and galectin-14, were mostly associated with cellular homeostasis maintaining and immune response. Haemonchus contortus infection induced gene expression in sheep T lymphocytes was measured at 0, 3, 30 and 60 days post infection. Four time-series experiments were performed at each sheep (2#, 3# and 5#).

2012-11-16 | E-GEOD-42302 | biostudies-arrayexpress

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Project description:Examined expression of microRNAs in different life-cycle stages and gut tissue of the pathogenic nematode Haemonchus contortus and identified differentially expressed miRNAs. Custom array contained probes to 609 Haemonchus contortus miRNA sequence (all mature and start miRNAs identified by Winter et al., 2012, BMC Genomics13:4; DOI: 10.1186/1471-2164-13-4) and all C. elegans sequences in miRBase release 16

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Project description:The Alpine goat Capra aegagrus hircus is parasitized by the barber pole worm (Haemonchus contortus). This relationship results in changes that affect the gene expression of the host, the pest, and the microbiome of both. Hematological parameters indicating genes that are expressed and/or the % Composition of abundant and diverse microbial flora are reflective of infestation. We identified responses to barber pole worms using blood-based analysis of transcripts and the microbiome. Seven (7) days post-inoculation (dpi) we identified 7,627 genes associated with different treatment types.

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Haemonchus contortus

Project description:Haemonchus contortus

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N-Glycome and N-Glycoproteome of a Hematophagous Parasitic Nematode Haemonchus

Project description:N-glycosylation is a physiologically vital post-translational modification of proteins in eukaryotic organisms. Initial work on Haemonchus contortus – an economically-important blood-sucking nematode of ruminants with a broad geographical distribution – has shown that the parasite harbors N-glycans with exclusive core chitobiose modifications, and severel immunogenic proteins (e.g., amino- and metallo-peptidases) in the adult worms are N-glycosylated. However, an informative atlas of N-glycosylation in H. contortus is not yet available. Herein, we report a total of 291 N-glycosylated proteins with 425 sites in this parasite. Functional analyses of glycoproteome revealed significant enrichment of the peptidase families (e.g., peptidase C1 and M1), many of which are potential vaccine targets. Besides, the glycan-rich conjugates are distributed primarily in the intestine and gonads of the adult worms. These data, taken together, provide a comprehensive insight into the N-glycosylation of a prevalent parasitic nematode, while underlining its significance for the infection and prophylaxis.

2021-09-09 | PXD023379 | Pride

Profiling of differentially expressed genes in sheep T lymphocytes response to Haemonchus contortus infection

2012-11-16 | GSE42302 | GEO

Haemonchus contortus strain:NZ_Hco_NP | isolate:Field

Project description:Haemonchus contortus NZ_Hco_NP

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Project description:Haemonchus contortus overview

| PRJNA193279 | ENA