Bifidobacteriaceae
Ontology highlight
ABSTRACT:
REPOSITORIES: ENA
Similar Datasets
Project description:HSP child-mother pairs and matched healthy child-mother pairs sequence.
| PRJNA497481 | ENA
Project description:Congenital toxoplasmosis is a fetal infection following the transplacental transmission of Toxoplasma gondii in a mother who seroconverted during pregnancy. Neonatal diagnosis has recently been improved through the identification by L’Ollivier et al. and Peyclit et al. of a congenital toxoplasmosis pathognomonic marker: the IgM triplet, corresponding to three bands of high molecular weight of 75, 90 and 100 kDa respectively found on the immunoblot pair profile mother-child. This is a new concept, as these three IgM bands do reflect an immunological response against proteins involved in mother-to-child transmission of Toxoplasma gondii. These proteins could be Toxoplasma gondii secreted effectors or not playing a role in the processes of invasion, modulation of the host cell immune system as well as in parasitic virulence. In this study, immunoproteomic techniques allowed us to identify 32 interesting protein spots on immunoblot, including 4 interesting spots specific to the IgM triplet. After protein identification of these spots by LC-MS/MS technique, we showed here that several Toxoplasma gondii proteins were good candidates for the IgM triplet. It turns out that each of these proteins is, directly or indirectly, involved in the process of cellular invasion and therefore probably in the process of transplacental invasion of Toxoplasma gondii. The identification of these proteins opens several fields of future diagnostic and therapeutic research that would improve management of congenital toxoplasmosis.
2025-12-08 | PXD060424 | Pride
Project description:Preterm birth is the major cause of newborn and infant mortality affecting nearly one in every ten live births. This study was designed to develop an epigenetic biomarker for susceptibility of preterm birth using buccal cells from the mother, father, and child (triads). MeDIP-seq was used to identify differential DNA methylation regions (DMRs) using a comparison of control term birth versus preterm birth triads. Epigenetic DMR associations with preterm birth were identified for both the mother and father that were distinct and suggest potential epigenetic contributions from both parents. The mother (165 DMRs) and female child (136 DMRs) at p<1e-04 had the highest number of DMRs and were highly similar suggesting potential epigenetic inheritance of the epimutations. The male child had negligible DMR associations. The DMR associated genes for each group involve previously identified preterm birth associated genes.
2022-03-09 | GSE194227 | GEO
Project description:Genome-wide DNA methylation profiling of 251 whole-blood samples from children aged 2 years from the ENID mother-child cohort in The Gambia.
2017-11-23 | GSE99863 | GEO
Project description:LC-MS/MS analysis formula was performed for sera from 22 mother-infant dyads with HLA-conferred susceptibility to type 1 diabetes that were weaned to either an extensively hydrolyzed or regular infant milk. The samples included three samples from each mother (at the beginning of third trimester, at the time of delivery and 3 months postpartum) and five samples from each child (cord blood, 3, 6, 9 and 12 months). Targeted proteomics was used to validate differences observed between the feeding groups.Correlations in protein intensities within the dyads were detected together with perinatal and age-related changes.
2024-05-27 | PXD046387 | Pride
Project description:Genomewide methylation profiles from three tissues (cord blood, placenta, venous blood) derived from 24 mother-child dyads. Data was assayed with the Illumina HumanMethylation 450K Beacdchip and processed with Illumina's GenomeStudio V2011.1 Methylation Module v1.9.0
2014-03-01 | GSE54399 | GEO