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Homo sapiens

ABSTRACT: Gene expression profiling of human endometrial stromal cells during decidualization

PROVIDER: PRJDB8748 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR190745_1.fastq.gz	Fastqsanger.gz
	DRR190745_2.fastq.gz	Fastqsanger.gz
	DRR190746_1.fastq.gz	Fastqsanger.gz
	DRR190746_2.fastq.gz	Fastqsanger.gz
	DRR190747_1.fastq.gz	Fastqsanger.gz

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Project description:Our previous studies have shown that C/EBPβ plays a critical role in human endometrial stromal decidualization. In order to identify the molecular pathways regulated by C/EBPβ during decidualization, we performed gene expression profiling using RNA isolated from normal and C/EBPβ-deficient human endometrial stromal cells. The microarray results revealed that several key regulators of stromal differentiation, such as BMP2, Wnt4, IL-11Rα and STAT3, operate downstream of C/EBPβ during decidualization. Further studies revealed that STAT3 is a direct target of C/EBPβ and plays an important role in cytokine signal during the decidualization process. Gene expression profiling, using STAT3-deficient HESCs, showed an extensive overlap of pathways downstream of STAT3 and C/EBPβ during stromal cell differentiation.

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