Project description:Analysis of differentially expressed genes in wild type SK-ES1 Ewing Sarcoma cells when compared to SK-ES1 Ewing Sarcoma cells that received six 4 Gy fractions (cumulative dose of 24 Gy) of ionizing radiation (radiation-adapted cell line). The hypothesis tested being that repeated ionizing radiation exposure of modifies radiation therapy response in Ewing Sarcoma.
Project description:To profile the proteome of intestinal epithelial IEC-6 cells in response to treatment with Akkermansia muciniphila, Bifidobacterium longum, or Akkermansia muciniphila + Bifidobacterium longum co-culture. In addition, we also add arabinoxylan (AX) to Akkermansia muciniphila + Bifidobacterium longum combination since we previously found that this glycan enhance their synergistic effect.
Project description:Ewings Sarcoma (ES) belongs to the group of bone cancers defined by the existence of a certain EWS-ETS fusion gene. In this study we use the model cell line CADO-ES1 (EWSR1-ERG fusion gene) to characterize the genomic structure in respect to CNV and fusion gene events.
Project description:Modulation of gut microbiota through probiotic supplementation is an interesting strategy to prevent obesity We use microarrays to study the global genome expression of C. elegans fed with the probiotic strain Bifidobacterium animalis sbsp. lactis CECT 8145
