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EndoC-bH1

ABSTRACT: Gene expression in EndoC-bH1 human beta-cell line

PROVIDER: PRJEB15283 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR1600757.fastq.gz	Fastqsanger.gz
	ERR1600757_1.fastq.gz	Fastqsanger.gz
	ERR1600757_2.fastq.gz	Fastqsanger.gz

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PCSK9 knockdown in EndoC-bH1 cells at 72 hours

Project description:The aim of the study was to characterize the role of PCSK9 in human beta cells. We performed siRNA-mediated knockdown of PCSK9 in human beta cell line EndoC-bH1 and compared the expression profiles against control siRNA-treated cells.

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Project description:We have developped a novel human pancreatic beta cell line: EndoC-βH5. EndoC-βH5 cells are ready-to-use and storable cells with physiological insulin secretion. EndoC-βH5 cells were generated by integrative gene transfer of immortalizing transgenes hTERT and SV40 large T along with Herpes Simplex Virus-1 thymidine kinase into human fetal pancreas. Immortalizing transgenes were removed after amplification using CRE activation and remaining non-excized cells eliminated using ganciclovir. Resulting cells were distributed as ready to use EndoC-βH5 cells. We performed comparative transcriptome analysis with EndoC-βH1 cells , extensive functional and immunological assays. RNA-seq confirmed abundant expression of beta cell transcription factors and functional markers, including incretin receptors.

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2022-04-07 | PXD027913 | Pride

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