Project description:Purpose: We evaluated T. interdigitale H6 and PacC-1 mutant transcriptome using high-throughput RNA-sequencing (RNA-seq) technology aiming to identify metabolic pathways modulated by the transcription factor PacC. Methods: We employed the next-generation sequencing (RNA-seq) approach to identify the central genes related to PacC in response to keratin. Results: PacC acts as a central regulator of fungal adaptation and virulence in keratin-rich conditions, coordinating nutrient uptake, keratin degradation, and oxidative stress responses. Its mutation causes severe metabolic imbalance and cellular stress. Conclusions: Our findings provide insights into a specific molecular function of PacC in a infection-like medium, highlighting PacC-dependent pH adaptation pathways as potential therapeutic targets in dermatophytoses.
2026-04-01 | GSE313401 | GEO
Project description:whole genome sequencing of Trichophyton interdigitale
