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T follicular helper cells promote a beneficial gut ecosystem for host metabolic homeostasis by sensing microbiota derived extracellular ATP

ABSTRACT: T follicular helper cells promote a beneficial gut ecosystem for host metabolic homeostasis by sensing microbiota derived extracellular ATP

PROVIDER: PRJEB19531 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR1854560.fastq.gz	Fastqsanger.gz
	ERR1854561.fastq.gz	Fastqsanger.gz
	ERR1854562.fastq.gz	Fastqsanger.gz
	ERR1854563.fastq.gz	Fastqsanger.gz
	ERR1854564.fastq.gz	Fastqsanger.gz

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T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP.

Project description:The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help.

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