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RNA-seq of murine CD4 T cells after pentanoate treatment compared to untreated control

ABSTRACT: RNA-seq of murine CD4 T cells after pentanoate treatment compared to untreated control

PROVIDER: PRJEB22924 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR2163581.fastq.gz	Fastqsanger.gz
	ERR2163582.fastq.gz	Fastqsanger.gz
	ERR2163583.fastq.gz	Fastqsanger.gz
	ERR2163584.fastq.gz	Fastqsanger.gz
	ERR2163585.fastq.gz	Fastqsanger.gz

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RNA-seq of murine CD4 T cells after pentanoate treatment compared to untreated control

Project description:To analyse the influence of pentanoate on the differentiation of naive CD4 T cells under Th17 inducing conditions, murine CD4 T cells were isolated from spleen and lymphnodes of FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice). The T cells were kept for 3 days under Th17 inducing conditions either with 4 mM pentanoate or without pentanoate (control).

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RNA-seq of murine spleen B-cells after pentanoate treatment compared to untreated control

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RNA-seq of murine spleen B-cells after pentanoate treatment compared to untreated control

Project description:We tested the influence of pentanoate on B cells by treatment of CpG-stimulated B cells in vitro. We isolated naive B cells from FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice) from spleen. Cells were cultured in presence of 5 µg/ml CpG 2395. 24h after CpG-stimulation, B cells were treated with 5 mM pentanoate or left untreated. Cells were harvested on day 4 after seeding.

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