Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Host-derived fecal microRNAs can indicate gut microbiota healthiness and ability to induce inflammation

ABSTRACT: Host-derived fecal microRNAs can indicate gut microbiota healthiness and ability to induce inflammation

PROVIDER: PRJEB32441 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR3309740.fastq.gz	Fastqsanger.gz
	ERR3309750.fastq.gz	Fastqsanger.gz
	ERR3309760.fastq.gz	Fastqsanger.gz
	ERR3309770.fastq.gz	Fastqsanger.gz
	ERR3309741.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 34

Similar Datasets

Host-derived fecal microRNAs can indicate gut microbiota healthiness and ability to induce inflammation.

Project description:Disruption of intestine-microbiota symbiosis can result in chronic gut inflammation. We hypothesize that assessing the initial inflammatory potential of the microbiota in patients is essential and that host-derived miRNAs, which can be found in feces, could fulfill this function. We investigated whether the gut microbiota composition impacts the fecal miRNA profile and thereby indicates its ability to influence intestinal inflammation. Methods: We used high-throughput qPCR to compare fecal miRNA profile between germ-free and conventional mice. Conventionalization of germfree mice by various colitogenic and non-colitogenic microbiotas (IL10-/- and TLR5-/- associated microbiota) was performed. Results: We identified 12 fecal miRNAs impacted by the presence of a microbiota. Conventionalization of germfree mice by various colitogenic and non-colitogenic microbiotas associated with the development of intestinal inflammation (IL10-/- and TLR5-/- associated microbiota) yielded distinctively altered fecal miRNA profiles compared to that of mice receiving a "healthy" microbiota. Correlation analysis revealed the existence of interactions between the 12 abovementioned miRNAs and specific microbiota members. Conclusion: These results showed that fecal miRNA profile can be differentially and specifically impacted by microbiota composition, and that miRNA could importantly serve as markers of the colitogenic potential of the microbiota. This is particularly relevant to assess individual state of the microbiota in patients with dysbiosis-related disorders, such as IBD and potentially determine their ability to respond to therapeutics.

| S-EPMC6599659 | biostudies-literature

Changes in cognitive ability and serum microRNAs during aging in mice

Project description:Changes in cognitive ability and serum microRNAs during aging in mice

| PRJNA1048312 | ENA

MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells

Project description:MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells

| PRJNA750650 | ENA

MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells

Project description:MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells

| PRJNA748665 | ENA

MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [CHIP_SEQ]

Project description:MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [CHIP_SEQ]

| PRJNA748673 | ENA

MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [RNA_SEQ]

Project description:MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [RNA_SEQ]

| PRJNA748672 | ENA

MicroRNAs among esophageal cancer cell sublines with different migration ability

Project description:Cellular directed migration is critical to invasion-metastasis cascade of cancer cells. We used in vitro transwell model to screen two esophageal cancer cell lines (KYSE30/180) and obtained two pairs of subpopulations with distinc motiliyt ability. Then we used microarrays to detail the differentially expressed genes and microRNAs between these two cell sublines (30U/D and 180U/D) to identify those responsible for ESCC motility.

2015-12-31 | GSE67509 | GEO

MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [Methylation_2 array]

Project description:MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [Methylation_2 array]

| PRJNA748620 | ENA

MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [expression array]

Project description:MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [expression array]

| PRJNA748606 | ENA

MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [Methylation_1 array]

Project description:MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells [Methylation_1 array]

| PRJNA748619 | ENA